HCID 23359035, 화합물 → 2,4-Difluoro-3,6-dimethylaniline

HRID 232652노트

반응식

HRID 232652 반응식
[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[CH:6]=[C:5]([CH2:11]SC)[C:3]=1[NH2:4]>[Ni].C(O)C>[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[CH:6]=[C:5]([CH3:11])[C:3]=1[NH2:4]

참가 물질

4

반응물 1

HCID 23359035HCID 23359035, 화합물

생성물 1

HCID 233590392,4-Difluoro-3,6-dimethylaniline수율 84.8%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매2회

실험 절차

To a solution of Raney nickel (50 g) in ethanol (100 ml) is added a solution of 2,4-difluoro-3-methyl-6-methylthiomethylaniline (4.79 g) in ethanol (30 ml) at room temperature with stirring, followed by stirring at room temperature for 30 minutes. The Raney nickel is filtered off and the filtrate is diluted with water, extracted with dichloromethane, and the extract is washed with water and dried. The solvent is distilled off under reduced pressure to give 2,4-difluoro-3,6-dimethylaniline (3.14 g).

후처리

  1. stirringby stirring at room temperature for 30 minutes
  2. filtrationThe Raney nickel is filtered off
  3. additionthe filtrate is diluted with water
  4. extractionextracted with dichloromethane
  5. washthe extract is washed with water
  6. customdried
  7. distillationThe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-30bbf59b6a494ba79d5c9790d1dd69ef
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591744

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