Thiophene-3-sulfonyl Chloride → HCID 12146375, 화합물

HRID 232748

반응식

HRID 232748 반응식
[S:1]1[CH:5]=[CH:4][C:3]([S:6](Cl)(=[O:8])=[O:7])=[CH:2]1.[NH2:10][C:11]1[O:15][N:14]=[C:13]([CH3:16])[C:12]=1[Br:17]>>[Br:17][C:12]1[C:13]([CH3:16])=[N:14][O:15][C:11]=1[NH:10][S:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)(=[O:8])=[O:7]

참가 물질

3

반응물 2

HCID 2776378Thiophene-3-sulfonyl ChlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 12146375HCID 12146375, 화합물수율 22%

실험 절차

N-(4-Bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from thiophene-3-sulfonyl chloride with 5-amino-4-bromo-3-methylisoxazole in 22% yield. Purification by column chromatography using 10% MeOH/CHCl3 as eluent gave a pale brown oil.

후처리

  1. customPurification by column chromatography
  2. customgave a pale brown oil

출처 및 근거

ORD 기록
ord-5648f23a8a5649a0a6503bd53864150c
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591761

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