Hydrochloric Acid → 4-(Chloromethyl)-2-(cyclopentyloxy)-1-methoxybenzene

HRID 232785

반응식

HRID 232785 반응식
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH2:10]O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:17]>C(Cl)Cl>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH2:10][Cl:17])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 111387063-Cyclopentyloxy-4-methoxybenzyl alcohol

생성물 1

HCID 109007664-(Chloromethyl)-2-(cyclopentyloxy)-1-methoxybenzene수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution containing 3-cyclopentyloxy-4-methoxybenzyl alcohol (112 grams, 0.50 mol), prepared as described in step a), in 1 liter of methylene chloride was stirred at room temperature with concentrated HCl (110 milliliters, 1.2 mol) for 3 hours, at which time the reaction was done by TLC. The layers were separated and the methylene chloride solution was washed twice with water and evaporated under reduced pressure to give 3-cyclopentyloxy-4-methoxybenzyl chloride (119 grams, 100%).

후처리

  1. customprepared
  2. customThe layers were separated
  3. washthe methylene chloride solution was washed twice with water
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-dd448689c9654bda9fceb89a24560c20
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591776

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