Pregnenolone → Isopregnanolone

HRID 232791

반응식

HRID 232791 반응식
[OH:1][C@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:18]2[CH2:17][CH2:16][C@@:15]2([CH3:23])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[H][H]>C(O)C.[Pd]>[OH:1][C@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[CH2:17][CH2:16][C@@:15]2([CH3:23])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1

참가 물질

5

반응물 2

HCID 8955PregnenoloneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 92787Isopregnanolone수율 96.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 3β-hydroxy-5-pregnen-20-one (980 mg, 316.5 g/m, 3.1 mmol) and 50 mg of 5% Pd/C in 50 mL of absolute ethyl alcohol was stirred under 1 atmosphere of hydrogen gas for 5 hours at room temperature. The reaction was filtered through a celite pad and the filtrate evaporated under reduced pressure to give 950 mg of 3β-hydroxy-5α-pregnan-20-one (96% yield).

후처리

  1. filtrationThe reaction was filtered through a celite pad
  2. customthe filtrate evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-46dff4cc51f745f9a769e0a0f3cd1dbe
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591733

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