Hydrochloric Acid → Methyl 5-Methoxy-2-methylbenzoate
반응식
Br[C:2]1[CH:3]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[C:5]([CH3:8])=[CH:6][CH:7]=1.Cl.CN(C)[CH:16]=[O:17]>[Cu](I)I>[CH3:16][O:17][C:2]1[CH:3]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[C:5]([CH3:8])=[CH:6][CH:7]=1참가 물질
5
실험 절차
12.6 g of a 28% sodium methylate methanol solution and 4.2 g of copper iodide were added to 5 g of methyl 4-bromo-toluate dissolved in 20 ml of dimethylformamide and the mixture was refluxed under heating for 2 hours. The reaction mixture was adjusted to about pH 2 by adding 1N-hydrochloric acid thereto and extracted with ethyl acetate. and the organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. The residue obtained by removing the solvent was applied to silica gel column chromatography to obtain 2.47 g of the title compound.
후처리
- temperaturethe mixture was refluxed
- temperatureunder heating for 2 hours
- extractionextracted with ethyl acetate
- washand the organic layer was washed with a saturated saline solution
- dry with materialdried over anhydrous sodium sulfate
- customThe residue obtained
- customby removing the solvent
출처 및 근거
- ORD 기록
- ord-beabbc0321ac4c0eb03c5d181ea16308
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05591752
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