Benzenesulfonyl chloride → 2-Bromobenzoic acid 2-phenylsulfonylhydrazide

HRID 233132

반응식

HRID 233132 반응식
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[C:12]1([S:18]([NH:7][NH:6][C:4](=[O:5])[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[Br:1])(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 1014602-Bromobenzohydrazide

생성물 1

HCID 77099642-Bromobenzoic acid 2-phenylsulfonylhydrazide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 2-bromobenzoic acid hydrazide (132 g) in pyridine (1.2 L) cooled to about 10 C. with an ice bath, was added benzensulfonyl chloride (78.3 ml). After complete addition, the reaction was stirred at ambient temperature for four hours, and then poured into ice-hydrochloric acid to precipitate a yellow solid, 135 g. The material was recrystallized from isopropanol to yield 125 g of 2-bromobenzoic acid 2-phenylsulfonylhydrazide, m.p.=154°-156° C.

후처리

  1. additionAfter complete addition
  2. customto precipitate a yellow solid, 135 g
  3. customThe material was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-4b5577dff231466cacbaf5ed9e5cd0ed
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591745

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