3-(1-Methylpyrrolidin-2-yl)pyridine → Nicotine beta-cyclodextrin

HRID 233419

반응식

HRID 233419 반응식
[CH2:1]([OH:77])[C@H:2]1[O:7][C@@H:6]2[O:8][C@H:9]3[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]4[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]5[C@H:32]([OH:33])[C@@H:31]([OH:34])[C@@H:30]([O:35][C@H:36]6[C@H:41]([OH:42])[C@@H:40]([OH:43])[C@@H:39]([O:44][C@H:45]7[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]8[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]1[C@H:4]([OH:76])[C@H:5]2[OH:75])[O:56][C@@H:55]8[CH2:63][OH:64])[O:47][C@@H:46]7[CH2:65][OH:66])[O:38][C@@H:37]6[CH2:67][OH:68])[O:29][C@@H:28]5[CH2:69][OH:70])[O:20][C@@H:19]4[CH2:71][OH:72])[O:11][C@@H:10]3[CH2:73][OH:74].[N:78]1[CH:83]=[C:82]([CH:84]2[CH2:89][CH2:88][CH2:87][N:85]2[CH3:86])[CH:81]=[CH:80][CH:79]=1>O>[N:78]1[CH:83]=[C:82]([CH:84]2[CH2:89][CH2:88][CH2:87][N:85]2[CH3:86])[CH:81]=[CH:80][CH:79]=1.[CH2:67]([OH:68])[C@H:37]1[O:38][C@@H:39]2[O:44][C@H:45]3[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]4[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]5[C@H:4]([OH:76])[C@@H:5]([OH:75])[C@@H:6]([O:8][C@H:9]6[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]7[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]8[C@H:32]([OH:33])[C@@H:31]([OH:34])[C@@H:30]([O:35][C@H:36]1[C@H:41]([OH:42])[C@H:40]2[OH:43])[O:29][C@@H:28]8[CH2:69][OH:70])[O:20][C@@H:19]7[CH2:71][OH:72])[O:11][C@@H:10]6[CH2:73][OH:74])[O:7][C@@H:2]5[CH2:1][OH:77])[O:56][C@@H:55]4[CH2:63][OH:64])[O:47][C@@H:46]3[CH2:65][OH:66]

참가 물질

4

반응물 2

HCID 9423-(1-Methylpyrrolidin-2-yl)pyridine2회HCID 444041beta-Cyclodextrin

생성물 1

HCID 131718770Nicotine beta-cyclodextrin

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

An initial quantity of 56.76 g of β-cyclodextrin was placed in a 400 mL beaker and 5.68 g of H2O (equivalent to 10% of the powder) was added with stirring. The water was added in amounts of 1.9 g at a time, with stirring for 10 minutes at each step. The powder, before addition of nicotine, was similar to a wet granulate. Next, 6.37 g of nicotine was added very slowly with stirring, and at the end of the process the granulate was stirred for 10 minutes. The obtained granulate was dried in an oven at 35° C. for 2 hours. A sample was then analyzed for nicotine content.

후처리

  1. additionwas added
  2. stirringwith stirring for 10 minutes at each step
  3. stirringwith stirring
  4. stirringat the end of the process the granulate was stirred for 10 minutes
  5. customThe obtained granulate was dried in an oven at 35° C. for 2 hours

출처 및 근거

ORD 기록
ord-3f374923ed2f4f029343ab95f445bc5e
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05593684

연결된 노트

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