HCID 54560818, 화합물 → (biphenyl-2-ylmethyl)phosphonic acid
반응식
C[O:2][P:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:6])[O:4]C>Cl>[C:9]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][P:3](=[O:2])([OH:6])[OH:4]참가 물질
3
실험 절차
A solution of ([1,1'-Biphenyl]-2-ylmethyl)phosphonic acid dimethyl ester (Compound 6, 515 mg, 1.87 mM) in concentrated hydrochloric acid (5 mL) is heated at reflux temperature for six hours. The reaction is then allowed to stand at room temperature until a white precipitate is formed. The aqueous HC1 is removed under reduced pressure. The white solid is recrystallized from water to yield 300 mg of title compound as white crystals, mp 168.5°-169° C.
후처리
- temperatureat reflux temperature for six hours
- customto stand at room temperature until a white precipitate
- customis formed
- customThe aqueous HC1 is removed under reduced pressure
- customThe white solid is recrystallized from water
출처 및 근거
- ORD 기록
- ord-64b33e3d8f594b7e872a68c62134ed10
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05593980
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