Cyclohexylthiourea → 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

HRID 23357

반응식

HRID 23357 반응식
Br[CH:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)[CH:3]=O.[CH:16]1([NH:22][C:23]([NH2:25])=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>CN(C)C=O>[CH:16]1([NH:22][C:23]2[S:24][C:2]([C:5]3[CH:14]=[C:13]4[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]4)=[CH:7][CH:6]=3)=[CH:3][N:25]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 1471603CyclohexylthioureaHCID 135531132Bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde

생성물 1

HCID 1354961657-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

후처리

  1. customThe mixture is quenched with 10% dimethylamine in ethanol
  2. customthe solvent is removed
  3. customThe crude is purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-25238562fd52496693cf85f9c426924f
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852720B2

연결된 노트

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