(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride → 7-methoxy-3-methylsulfanyl-1H-indole

HRID 23380노트

반응식

HRID 23380 반응식
[Cl-].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[C:9]2[S+:13](C)[CH3:14]>CS(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[C:9]2[S:13][CH3:14]

참가 물질

3

반응물 1

HCID 22573983(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

생성물 1

HCID 225741157-methoxy-3-methylsulfanyl-1H-indole수율 87.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

후처리

  1. customplaced under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
  2. customThe flask was placed on a steam bath
  3. temperatureheated until the bubbling
  4. temperaturethe reaction mixture was cooled
  5. custompartitioned between ether and water
  6. customThe organic layer was dried
  7. filtrationfiltered
  8. customevaporated to dryness

출처 및 근거

ORD 기록
ord-0313e01f608f4c7bb8da78f078c1e2b2
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852726B2

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