4-Methylbenzaldehyde → 1,3-Bis(4-methylphenyl)prop-2-en-1-one

HRID 234070

반응식

HRID 234070 반응식
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1.[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1>O.C(O)C>[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[CH:11][C:10]([C:7]2[CH:8]=[CH:9][C:4]([CH3:3])=[CH:5][CH:6]=2)=[O:12])=[CH:16][CH:15]=1

참가 물질

6

반응물 3

HCID 77254-MethylbenzaldehydeHCID 8500p-METHYLACETOPHENONEHCID 14798Sodium Hydroxide

생성물 1

HCID 2565521,3-Bis(4-methylphenyl)prop-2-en-1-one수율 92.2%

시약·촉매·용매 2

HCID 702Ethanol용매3회HCID 962Water용매

실험 절차

To a solution of 0.97 g of sodium hydroxide in 9.7 ml of water was added 27.1 ml of ethanol. A solution of 2.563 g of p-methylacetophenone in 4 ml of ethanol was added dropwise to the mixture, followed by dropwise addition of a solution of 2.30 g of p-methylbenzaldehyde in 4 ml of ethanol. The resulting mixture was stirred at room temperature for 3.75 hours, and the solid matter was filtered, washed with cold water and ethanol and thoroughly desiccated to give 4.16 g of 4,4'-dimethylchalcone.

후처리

  1. filtrationthe solid matter was filtered
  2. washwashed with cold water and ethanol

출처 및 근거

ORD 기록
ord-9c1f169da84d41449caa0f4bc05d95b2
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594081

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