Sodium Hydroxide → 3-(2-Bromophenyl)propionic acid

HRID 234076

반응식

HRID 234076 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([O:12]C)=[O:11].[OH-].[Na+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 15712815Methyl 3-(2-bromophenyl)propanoate

생성물 1

HCID 3160103-(2-Bromophenyl)propionic acid수율 96.1%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of methyl 3-(2-bromophenyl)propionate (35.77 g) in ethanol (80.7 ml) was added at room temperature dropwise a solution of sodium hydroxide (11.77 g) in water (40 ml). After the reaction mixture was stirred under reflux for 2.5 hrs. and left standing for cooling, methanol was removed by distillation under reduced pressure, the residue was poured into ice-hydrochloric acid and stirred for 20 minutes. Crystalline precipitates were filtered, washed well with water, dried under reduced pressure to give the title compound (32.4 g).

후처리

  1. temperatureunder reflux for 2.5 hrs
  2. waitand left standing
  3. temperaturefor cooling
  4. custommethanol was removed by distillation under reduced pressure
  5. additionthe residue was poured into ice-hydrochloric acid
  6. stirringstirred for 20 minutes
  7. customCrystalline precipitates
  8. filtrationwere filtered
  9. washwashed well with water
  10. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-aa64c040a29d4ca19be381a75352ec36
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594081

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