Kojic Acid → 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one

HRID 234149

반응식

HRID 234149 반응식
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].C(=O)([O-])[O-].[K+].[K+].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C=O)C>[CH2:17]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 3840Kojic AcidHCID 7503Benzyl ChlorideHCID 11430Potassium Carbonate

생성물 1

HCID 9015985-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one수율 75.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To the solution of kojic acid (28 g) in DMF (200 ml) was added potassium carbonate (32 g), and the mixture was stirred at room temperature for 30 minutes. After benzyl chloride (25 g) was added, the mixture was further stirred for 60 minutes. The solvent was evaporated. The residue was then extracted with ethyl acetate, washed with water and dried. After the solvent was evaporated, the residue was crystallized from ethyl acetate to give 5-benzyloxy-2-hydroxymethyl-4-oxo-4H-pyran (34.6 g).

후처리

  1. stirringthe mixture was further stirred for 60 minutes
  2. customThe solvent was evaporated
  3. extractionThe residue was then extracted with ethyl acetate
  4. washwashed with water
  5. customdried
  6. customAfter the solvent was evaporated
  7. customthe residue was crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-e50df54098a84e479a9dd6dc06e6abaf
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594004

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