Water → HCID 178418251, 화합물

HRID 2343

반응식

HRID 2343 반응식
[CH2:1]([C:5]1[NH:6][C:7]([CH2:11][OH:12])=[C:8]([Cl:10])[N:9]=1)[CH2:2][CH2:3][CH3:4].O>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([C:5]1[NH:6][C:7]([CH:11]=[O:12])=[C:8]([Cl:10])[N:9]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 2

HCID 962WaterHCID 27356622-Butyl-4-chloro-5-(hydroxymethyl)imidazole

생성물 1

HCID 178418251HCID 178418251, 화합물수율 86.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

A stirred mixture of 2-n-butyl-4-chloro-5-hydroxymethylimidazole (15.00 g, 0.0795 mol) and activated manganese dioxide (40.00 g) in 600 ml of methylene chloride was refluxed for 24 h using a water separator. The mixture was filtered hot through a Celite® pad. The Celite® pad was washed several times with hot methylene chloride. The washings were combined with the filtrate and concentrated in vacuo to give 12.81 g (86%) of the aldehyde as a white solid; mp 97°-98° C.

후처리

  1. temperaturewas refluxed for 24 h
  2. filtrationThe mixture was filtered hot through a Celite® pad
  3. washThe Celite® pad was washed several times with hot methylene chloride
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0fdf59899d7d46d0ae418ee316a592b9
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728842

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