Iodoethane → 2-Ethyl-5-methylbenzo[b]thiophene

HRID 234388

반응식

HRID 234388 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.[Li][C:12](C)(C)[CH3:13].C(I)C>C1COCC1>[CH2:12]([C:7]1[S:6][C:5]2[CH:9]=[CH:10][C:2]([CH3:1])=[CH:3][C:4]=2[CH:8]=1)[CH3:13]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 843465-Methylbenzo(b)thiopheneHCID 178418306HCID 178418306, 화합물

생성물 1

HCID 5953442-Ethyl-5-methylbenzo[b]thiophene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-ethyl-5-methylbenzo[b]thiophene was prepared in the same manner as described in Example 40A. Reaction of 5-methylbenzo[b]thiophene (3.4 mmoles, 0.50 g), t-BuLi (1.7 m, 5.1 mmoles, 3.0 ml) and ethyl iodide (6.8 mmoles, 0.54 ml) in THF (10 ml) yielded 0.58g (97%) of a light yellow liquid.

출처 및 근거

ORD 기록
ord-ebcd1db488524e9e9c2b9e58d2a4e804
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594021

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