Trityl chloride → 4-Iodo-1-(triphenylmethyl)-1H-pyrazole

HRID 23446

반응식

HRID 23446 반응식
[I:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.[C:7]1([C:13](Cl)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C>CN(C=O)C>[C:13]([N:4]1[CH:3]=[C:2]([I:1])[CH:6]=[N:5]1)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 770224-Iodopyrazole

생성물 1

HCID 153244794-Iodo-1-(triphenylmethyl)-1H-pyrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared by combining 4-iodopyrazole (10 g, 52 mmol), triphenylmethyl chloride (14.4 g, 51.6 mmol), triethylamine (NEt3) (7.2 mL, 52 mmol), and DMF (80 mL). After stirring overnight, the mixture was poured onto ice water. The precipitated solid was collected and recrystallized to give the title compound as a solid, mp 193-194° C.

후처리

  1. customThe title compound was prepared
  2. additionthe mixture was poured onto ice water
  3. customThe precipitated solid was collected
  4. customrecrystallized

출처 및 근거

ORD 기록
ord-d3ef2a74458c4b448cd736d864cc3c8b
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852711B2

연결된 노트

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