4-Methyl-1-penten-3-ol → 1-Furan-3-yl-4-methyl-pentan-3-one

HRID 23449

반응식

HRID 23449 반응식
Br[C:2]1[CH:6]=[CH:5][O:4][CH:3]=1.[CH3:7][CH:8]([CH3:13])[CH:9]([OH:12])[CH:10]=[CH2:11].C(=O)(O)[O-].[Na+]>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.CN(C=O)C>[O:4]1[CH:5]=[CH:6][C:2]([CH2:11][CH2:10][C:9](=[O:12])[CH:8]([CH3:13])[CH3:7])=[CH:3]1

참가 물질

7

반응물 3

HCID 209294-Methyl-1-penten-3-olHCID 891643-BromofuranHCID 516892Sodium Bicarbonate

생성물 1

HCID 225730251-Furan-3-yl-4-methyl-pentan-3-one

시약·촉매·용매 3

HCID 70681Tetrabutylammonium Chloride촉매HCID 167845palladium(II) acetate촉매HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared according to General Method 4a using 3-bromofuran (17 mmol), 4-methyl-1-penten-3-ol (25.5 mmol), tetrabutyl ammonium chloride (17 mmol), sodium bicarbonate (42.5 mmol), DMF (15 mL), and palladium acetate (0.9 mmol). The title compound was flash chromatographed eluting with EtOAc:hexane (5:95 to 10:90).

후처리

  1. customThe title compound was prepared
  2. customchromatographed
  3. washeluting with EtOAc:hexane (5:95 to 10:90)

출처 및 근거

ORD 기록
ord-a211614668054fd4ad48f16105273d61
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852711B2

연결된 노트

불러오는 중…