Benzoyl chloride → 3-(Benzoyloxy)-4-methyl-1,3-thiazole-2(3H)-thione

HRID 234783노트

반응식

HRID 234783 반응식
[OH:1][N:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]1=[S:8].C(=O)([O-])O.[Na+].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O>[C:14]([O:1][N:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]1=[S:8])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 3415933-Hydroxy-4-methyl-2(3H)-thiazolethioneHCID 516892Sodium Bicarbonate

생성물 1

HCID 233556233-(Benzoyloxy)-4-methyl-1,3-thiazole-2(3H)-thione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.735 parts of 3-hydroxy-4-methylthiazol-2(3H)-thione were stirred in 50 parts of water and 0.84 parts of sodium hydrogen carbonate. The solution was screened and 0.9 parts of benzoyl chloride were added. The reaction mixture was stirred overnight at room temperature. A precipitate was formed which was separated by filtration, washed with cold water and recrystallised from ethanol to give 3-benzoyloxy-4-methylthiazol-2(3H)-thione, m.pt. 100°-102° C. By analysis the composition was found to be C 52.4% wt; H 3.6% wt; N 5.6% wt and S 25% wt. C11H9NO2S2 requires C 52.6% wt; H 3.6% wt; N 5.6% wt and S 25.5% wt.

후처리

  1. customA precipitate was formed which
  2. customwas separated by filtration
  3. washwashed with cold water
  4. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-5f57f49aa6a847d080a6a57537929bd9
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05596102

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