Methanol → 4-(6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-sulfonyl)-benzonitrile

HRID 23481노트

반응식

HRID 23481 반응식
[C:1]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][N:11]2[S:14]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:7][C:6]=1[S:25]C#N)([CH3:4])([CH3:3])[CH3:2].S.[Na].[BH4-].[Na+].CO>CC(O)=O.O>[C:1]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][N:11]2[S:14]([C:17]2[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=2)(=[O:15])=[O:16])=[CH:7][C:6]=1[SH:25])([CH3:4])([CH3:2])[CH3:3]

참가 물질

7

반응물 4

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 225730724-(6-tert-Butyl-5-thiocyanato-2,3-dihydro-indole-1-sulfonyl)-benzonitrileHCID 86586439Sodium hydrogen sulphide

생성물 1

HCID 225728314-(6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-sulfonyl)-benzonitrile

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

The title compound was prepared according to the General Method 14b using 4-(6-tert-butyl-5-thiocyanato-2,3-dihydro-indole-1-sulfonyl)-benzonitrile (prepared in Example MM; 6.0 g, 15 mmol), sodium hydrogen sulfide (2.53 g, 45.3 mmol), sodium borohydride (3.43 g, 90.7 mmol), MeOH (10 mL), water (5 mL), and AcOH (5 mL). The crude product was used further without any purification.

후처리

  1. customThe crude product was used further without any purification

출처 및 근거

ORD 기록
ord-60585d43bbcc4dc0a8de861a78eab22a
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852711B2

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