2,3-Dichlorobenzaldehyde → (2,3-Dichlorophenyl)methanol

반응식

[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]

참가 물질

반응물 2

HCID 357452,3-Dichlorobenzaldehyde

HCID 4311764Sodium borohydride

생성물 1

HCID 228603(2,3-Dichlorophenyl)methanol

실험 절차

To a solution of 2,3-dichlorobenzaldehyde (Aldrich, 50 gms) in alcohol (800 mL) at room temperature was added NaBH4 (8.54 gms) and the resulting mixture stirred for 1.5 hours. The reaction was quenched with water and the solvent evaporated in vacuo before partitioning the residue between CHCl3 and saturated NaHCO3 solution. The organic phase was washed with brine, dried over MgSO4, filtered and the solvent evaporated in vacuo to leave a white solid, 48.38 gms, mp. 87°-87.5° C.

후처리

customThe reaction was quenched with water
customthe solvent evaporated in vacuo
custombefore partitioning the residue between CHCl3 and saturated NaHCO3 solution
washThe organic phase was washed with brine
dry with materialdried over MgSO4
filtrationfiltered
customthe solvent evaporated in vacuo
customto leave a white solid, 48.38 gms, mp. 87°-87.5° C.

출처 및 근거

ORD 기록: ord-b1c1dfe01eac405b9c790686f83ae6d9
출처 데이터셋: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05597827

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