Thionyl Chloride → 3,5-Dichlorobenzyl chloride

HRID 234935

반응식

HRID 234935 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5]O.S(Cl)([Cl:13])=O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5][Cl:13]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 432363,5-Dichlorobenzylic alcohol

생성물 1

HCID 1378803,5-Dichlorobenzyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3,5-dichlorobenzyl alcohol (Aldrich, 25 g) , thionyl chloride (100 ml) and DMF (0.5 ml) was stirred and refluxed for 4 hours. After cooling the mixture was concentrated in vacuo, the residue was taken up in ether, washed with saturated aqueous NaHCO3 and brine, dried (MgSO4) and concentrated in vacuo to give 3,5-dichlorobenzyl chloride as a light yellow solid, which was used without further purification, 28 g, mp. 32°-36° C.

후처리

  1. temperaturerefluxed for 4 hours
  2. temperatureAfter cooling the mixture
  3. concentrationwas concentrated in vacuo
  4. washwashed with saturated aqueous NaHCO3 and brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0e68d73215e841639b2447213a833f42
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597827

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