Thionyl Chloride → 3,5-Dichlorobenzyl chloride
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5]O.S(Cl)([Cl:13])=O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5][Cl:13]참가 물질
4
실험 절차
A mixture of 3,5-dichlorobenzyl alcohol (Aldrich, 25 g) , thionyl chloride (100 ml) and DMF (0.5 ml) was stirred and refluxed for 4 hours. After cooling the mixture was concentrated in vacuo, the residue was taken up in ether, washed with saturated aqueous NaHCO3 and brine, dried (MgSO4) and concentrated in vacuo to give 3,5-dichlorobenzyl chloride as a light yellow solid, which was used without further purification, 28 g, mp. 32°-36° C.
후처리
- temperaturerefluxed for 4 hours
- temperatureAfter cooling the mixture
- concentrationwas concentrated in vacuo
- washwashed with saturated aqueous NaHCO3 and brine
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0e68d73215e841639b2447213a833f42
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05597827
반응 노트
불러오는 중…