Methanol → 6-tert-Butyl-7-mercapto-1,4-dihydro-quinoxaline-2,3-dione

HRID 23498노트

반응식

HRID 23498 반응식
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[S:15]C#N)[NH:11][C:10](=[O:18])[C:9](=[O:19])[NH:8]2)([CH3:4])([CH3:3])[CH3:2].S.[Na].[BH4-].[Na+].CO>CC(O)=O.O>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[SH:15])[NH:11][C:10](=[O:18])[C:9](=[O:19])[NH:8]2)([CH3:4])([CH3:2])[CH3:3]

참가 물질

7

반응물 4

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 225728766-Tert-butyl-7-thiocyanato-1,4-dihydro-quinoxaline-2,3-dioneHCID 86586439Sodium hydrogen sulphide

생성물 1

HCID 225727956-tert-Butyl-7-mercapto-1,4-dihydro-quinoxaline-2,3-dione

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

The title compound was prepared according to General Method 14b using 6-tert-butyl-7-thiocyanato-1,4-dihydro-quinoxaline-2,3-dione (prepared in Example CCC; 1.5 g, 9.1 mmol), sodium hydrogen sulfide (0.51 g, 27 mmol), sodium borohydride (2.1 g, 55 mmol). MeOH (30 mL), H2O (3 mL), and glacial AcOH (5 mL). The crude product was used without purification. MS(APCI): 251 (M+H).

후처리

  1. customThe crude product was used without purification

출처 및 근거

ORD 기록
ord-c1fb75527546481183c8b2513d97bd04
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852711B2

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