Propylene Oxide → alpha,2,6-Trimethylmorpholin-4-ylethanol

HRID 2351020

반응식

[CH3:1][CH:2]1[O:7][CH:6]([CH3:8])[CH2:5][NH:4][CH2:3]1.[CH2:9]1[O:12][CH:10]1[CH3:11]>>[CH3:8][CH:6]1[O:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:9][CH:10]([OH:12])[CH3:11])[CH2:5]1

참가 물질

반응물 2

HCID 6378Propylene Oxide

HCID 1108622,6-Dimethylmorpholine

생성물 1

HCID 98999alpha,2,6-Trimethylmorpholin-4-ylethanol

실험 절차

The compound 2,6-dimethyl-N-(2-hydroxypropyl) morpholine was prepared by the method of Example 1 from 100.56 grams 2,6-dimethylmorpholine (0.87 moles) and 50.53 grams of propylene oxide (0.87 moles). Distillation of the reaction mixture gave 116.1 grams (76.8%) of the alcohol as a pale yellow oil, bp 70°-72° C. at 0.25 mm of Hg. The following elemental analysis was obtained: calc. 62.4 C, 11.1 H, 8.1 N; found 62.0 C, 10.8 H, 8.0 N.

후처리

distillationDistillation of the reaction mixture

출처 및 근거

ORD 기록: ord-96a871279f7c460babfeb3075f14be22
출처 데이터셋: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04871845

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