Sulfuric Acid → 2,4,5-Trifluorobenzamide

HRID 2351027

반응식

HRID 2351027 반응식
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:13]>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:13]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 5938132,4,5-Trifluorobenzonitrile

생성물 1

HCID 27769582,4,5-Trifluorobenzamide

실험 절차

In 20 ml of 80% sulfuric acid was dissolved 5.8 g of 2,4,5-trifluorobenzonitrile and the mixture was heated under reflux for 30 minutes. After cooling, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was dried over sodium sulfate and the solvent was removed to yield 5.32 g of 2,4,5-trifluorobenzamide.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extract was dried over sodium sulfate
  6. customthe solvent was removed

출처 및 근거

ORD 기록
ord-02bb96cf642d4a6db1a242a2bebdc1e3
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04871852

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