2-(1,2-Dibromoethyl)pyridine hydrobromide → 7-Ethoxy-2,3-dihydro-2-(2-pyridyl)thiazolo[3,2-a]benzimidazole

HRID 2351293노트

반응식

HRID 2351293 반응식
[CH2:1]([O:3][C:4]1[CH:13]=[CH:12][C:7]2[N:8]=[C:9]([SH:11])[NH:10][C:6]=2[CH:5]=1)[CH3:2].CC(C)([O-])C.[K+].Br.Br[CH:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[CH2:23]Br>CC(O)(C)C>[CH2:1]([O:3][C:4]1[CH:13]=[CH:12][C:7]2[N:8]3[CH2:23][CH:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)[S:11][C:9]3=[N:10][C:6]=2[CH:5]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 198460922-(1,2-Dibromoethyl)pyridine hydrobromideHCID 23665647Potassium tert-butoxideHCID 178466039HCID 178466039, 화합물

생성물 1

HCID 198460997-Ethoxy-2,3-dihydro-2-(2-pyridyl)thiazolo[3,2-a]benzimidazole

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

5-Ethoxy-2-mercaptobenzimidazole (6.03 g) was suspended in 2-methylpropan-2-ol (100 ml) at 50° C. Potassium tert-butoxide (3.48 g) was added and the mixture stirred for 1 hour. The temperature was allowed to fall to 35° C. and 2-(1,2-dibromoethyl)pyridine hydrobromide (10.76 g) was added. The resulting mixture was stirred for 1 hour at 35° C. and then 2 hours at reflux.

후처리

  1. customto fall to 35° C.
  2. stirringThe resulting mixture was stirred for 1 hour at 35° C.
  3. temperature2 hours at reflux

출처 및 근거

ORD 기록
ord-38f517fd53104a3ab0c865603b9537f6
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873237

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