Triethylamine → N-{[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]methyl}formamide

HRID 2351312노트

반응식

HRID 2351312 반응식
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH2:9][N+:10]#[C-:11])[N:5]=2)CC1.C1([C:15]2[O:19]N(C)C(NC=O)N=2)CC1.C(N(CC)CC)C.[O:31]=P(Cl)(Cl)Cl>C(Cl)Cl.O>[CH:11]([NH:10][CH2:9][C:6]1[N:5]=[C:4]([CH2:1][O:19][CH3:15])[O:8][N:7]=1)=[O:31]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 24813Phosphorus oxychlorideHCID 107493421,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)-HCID 867411005-Cyclopropyl-3-formylamino-methyl1,2,4-oxadiazole

생성물 1

HCID 14460545N-{[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]methyl}formamide

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCl3 (60 mmol) at 0° C. The mixture was then left for 30 minutes with stirring at 0° C., whereafter a solution of Na (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil. The oil was processed without any further purification. The compound was characterized by its IR absorbtion band at 2160 cm-1.

후처리

  1. additionwas added
  2. customevaporated in vacuo
  3. additionThe residue was treated with ether
  4. customdecanted
  5. customthe solution was evaporated

출처 및 근거

ORD 기록
ord-19957d3343934eab8021677ad444dc5c
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04873244

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