Isobutyraldehyde → HCID 67909148, 화합물

반응식

[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][NH2:27])=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[CH:29](=O)[CH:30]([CH3:32])[CH3:31]>>[ClH:1].[ClH:1].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][N:27]=[CH:29][CH:30]([CH3:32])[CH3:31])=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

참가 물질

반응물 2

HCID 6561Isobutyraldehyde

HCID 19913985HCID 19913985, 화합물

생성물 1

HCID 67909148HCID 67909148, 화합물수율 71%

실험 절차

In a similar manner to Example 8 reaction of 2 g of (RS)-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-6-hydrazinopyridazine dihydrochloride with (1.1 ml) of isobutyraldehyde afforded the title compound in 71% yield, m.p. 150°-152° C. (with decomp).

출처 및 근거

ORD 기록: ord-ed0eb595c4b84c8e882f9755853a387c
출처 데이터셋: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04873328

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