Sodium borohydride → HCID 10756510, 화합물

HRID 235199노트

반응식

HRID 235199 반응식
[C:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:12][CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>CO>[OH:9][CH:8]([C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:15]=1)[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 10709050HCID 10709050, 화합물

생성물 1

HCID 10756510HCID 10756510, 화합물수율 100.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 20.0 g of methyl 4-[4-(phenylacetyl)phenyl]butyrate in 200 ml of methanol, 2.52 g of sodium borohydride was added portionwise under ice-cooling, and stirring was continued for 1 hour. After the reaction solvent was removed under reduced pressure, the residue was added with water and then extracted with ether. After the ether layer was washed with water and dried, the solvent was removed to yield 20.3 g of pale yellow oil.

후처리

  1. additionwas added portionwise under ice-
  2. temperaturecooling
  3. customAfter the reaction solvent was removed under reduced pressure
  4. additionthe residue was added with water
  5. extractionextracted with ether
  6. washAfter the ether layer was washed with water
  7. customdried
  8. customthe solvent was removed

출처 및 근거

ORD 기록
ord-4d93a87cc39344ffbe9de88a23eceed3
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597848

반응 노트

불러오는 중…