2-Acetylpyridine → 3-Dimethylamino-1-(2-pyridyl)prop-2-en-1-one

HRID 2352187

반응식

HRID 2352187 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2].CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH3:15])[CH:14]=[CH:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)=[O:3]

참가 물질

3

반응물 2

HCID 142862-AcetylpyridineHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 5669933-Dimethylamino-1-(2-pyridyl)prop-2-en-1-one

실험 절차

A solution of 250 ml of 2-acetylpyridine and 500 ml of N,N-dimethylformamide dimethyl acetal was heated on a steam bath for 6 hours. After concentrating the reaction solution under vacuum, 1 liter of hexane was added to the part crystalline residue. The product was collected as small crystalline particles which were washed with an additional liter of hexane. Air drying was followed by drying at 45° C. under vacuum, leaving 350.7 g of 3-dimethylamino-1-(2-pyridinyl)-2-propen-1-one.

후처리

  1. concentrationAfter concentrating the reaction solution under vacuum, 1 liter of hexane
  2. additionwas added to the part crystalline residue
  3. customThe product was collected as small crystalline particles which
  4. washwere washed with an additional liter of hexane
  5. customAir drying
  6. customby drying at 45° C. under vacuum

출처 및 근거

ORD 기록
ord-960cfaa30cc64ec4a7b226743e3e7dc4
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04876252

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