Water → 4-Methyl-2-undecyl-2-oxazoline-4-methanol

HRID 2352199노트

반응식

HRID 2352199 반응식
[C:1]([OH:14])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[NH2:15][C:16]([CH3:21])([CH2:19]O)[CH2:17][OH:18].O>C1(C)C(C)=CC=CC=1.C(OCC)(=O)C>[OH:18][CH2:17][C:16]1([CH3:21])[CH2:19][O:14][C:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[N:15]1

참가 물질

6

반응물 3

HCID 962WaterHCID 15312-Amino-2-methyl-1,3-propanediolHCID 3893Lauric Acid

생성물 1

HCID 735074-Methyl-2-undecyl-2-oxazoline-4-methanol수율 84.6%

시약·촉매·용매 2

HCID 7237O-Xylene용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 20.03 g (100 mmoles) of dodecanoic acid and 11.57 g (110) mmoles) of 2-amino-2-methyl-1,3propanediol in 10 ml of xylene was heated for 30 hours at 185°-190°C. with azeotropic removal of water. The reaction mixture was taken up in ethyl acetate and was washed with water to remove excess amino alcohol. The organic layer was dried, concentrated and the residue was distilled at 152°-155° C./ 1 mmHg to give 22.8 g (84.6%) of 4-hydroxymethyl-4-methyl-2-undecyl-2oxazoline.

후처리

  1. washwas washed with water
  2. customto remove excess amino alcohol
  3. customThe organic layer was dried
  4. concentrationconcentrated
  5. distillationthe residue was distilled at 152°-155° C./ 1 mmHg

출처 및 근거

ORD 기록
ord-60fe064ac7264cf1aefd49c9da80aac9
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04876249

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