Thionyl Chloride → (E)-4-Fluorocinnamoyl chloride

HRID 2352315

반응식

HRID 2352315 반응식
[F:1][C:2]1[CH:12]=[CH:11][C:5](/[CH:6]=[CH:7]/[C:8](O)=[O:9])=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:12]=[CH:11][C:5](/[CH:6]=[CH:7]/[C:8]([Cl:15])=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 15302344-Fluorocinnamic acid

생성물 1

HCID 5706471(E)-4-Fluorocinnamoyl chloride수율 105.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 15.0 g. (0.09 mole) of trans-4-fluorocinnamic acid (Compound LXXVI) and 30 ml. (0.41 mole) of thionyl chloride in 100 ml. of toluene is stirred at 70° C. for 18 hours, and the solvent is evaporated at reduced pressure to obtain the crude product (17.5 g. (>100%)).

후처리

  1. additionA mixture of 15.0 g
  2. customthe solvent is evaporated at reduced pressure

출처 및 근거

ORD 기록
ord-776ffac4160a49d59cd8051d63e04376
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04876280

연결된 노트

불러오는 중…