Sodium borohydride → 7,12-Dioxaspiro[5.6]dodecane-9-methanol

HRID 2353노트

반응식

HRID 2353 반응식
[CH:1]([CH:3]1[CH2:14][CH2:13][O:12][C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[O:5][CH2:4]1)=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][CH:3]1[CH2:14][CH2:13][O:12][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2)[O:5][CH2:4]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 109545329-Formyl-7,12-dioxaspiro[5,6]dodecane

생성물 1

HCID 110308447,12-Dioxaspiro[5.6]dodecane-9-methanol

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
10 °C

실험 절차

To a solution of 9-formyl-7, 12-dioxaspiro[5,6]dodecane of formula IV (5 g) in methanol (15 ml) was added in small portions NaBH4 (0.5 g) while stirring the solution and maintaining the temperature at 10° C. After complete addition, the reaction mixture was stirred for 3 hr at 20° C. The product residue obtained after evaporation of methanol was treated with water (20 ml), extracted into ether and dried over K2CO3. Evaporation of ether gave 9-hydroxymethyl-7, 12-dioxaspiro[5,6]dodecane of formula V (5 g) of the drawings as colorless viscous liquid.

후처리

  1. additionAfter complete addition
  2. stirringthe reaction mixture was stirred for 3 hr at 20° C
  3. customThe product residue obtained
  4. customafter evaporation of methanol
  5. additionwas treated with water (20 ml)
  6. extractionextracted into ether
  7. dry with materialdried over K2CO3
  8. customEvaporation of ether

출처 및 근거

ORD 기록
ord-68ed201820eb41f482bf2de3bfa7daba
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728848

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