N-Iodosuccinimide → 6-Chloro-3-iodoimidazo[1,2-b]pyridazine
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[I:11]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1참가 물질
4
실험 절차
14 g of 6-chloroimidazo[1,2-b]pyridazine (Example 1.0) were suspended in 364 ml of acetonitrile, and 20.51 g of N-iodosuccinimide were added. The mixture was stirred at RT for 19 hours. A further 4.31 g of N-iodosuccinimide were added, and the mixture was stirred for 24 hours. The reaction was cooled and the precipitated solid was filtered off with suction, washed with acetonitrile and dried. 17.67 g of the desired product are obtained.
후처리
- stirringthe mixture was stirred for 24 hours
- temperatureThe reaction was cooled
- filtrationthe precipitated solid was filtered off with suction
- washwashed with acetonitrile
- customdried
출처 및 근거
- ORD 기록
- ord-64e5ad2189f343bab1c797771545ad9a
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07750000B2
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