Hydrochloric Acid → Methyl (4-phenylbicyclo[2.2.2]oct-1-yl)acetate

HRID 2353087노트

반응식

Cl.[C:2]1([C:8]23[CH2:15][CH2:14][C:11]([CH2:16][C:17]([OH:19])=[O:18])([CH2:12][CH2:13]2)[CH2:10][CH2:9]3)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20]O>>[C:2]1([C:8]23[CH2:9][CH2:10][C:11]([CH2:16][C:17]([O:19][CH3:20])=[O:18])([CH2:14][CH2:15]2)[CH2:12][CH2:13]3)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 887Methanol2회

HCID 21675351(4-Phenylbicyclo[2.2.2]oct-1-yl)acetic acid

생성물 1

HCID 25016427Methyl (4-phenylbicyclo[2.2.2]oct-1-yl)acetate

실험 절차

A freshly prepared solution of hydrogen chloride in methanol (˜3 M; ˜2 mL, ˜6 mmol) was added to a solution of (4-Phenylbicyclo[2.2.2]oct-1-yl)acetic acid (0.3 g) in methanol (3 mL) under a calcium chloride guard tube and the mixture stirred for 4 h. The solvent was evaporated to leave the title compound as an off white solid (0.25 g; 78%).

후처리

customThe solvent was evaporated

출처 및 근거

ORD 기록: ord-0d286cb3e9264c749958da6bb75af05e
출처 데이터셋: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07749997B2

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