Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-[4-(4-Iodo-phenoxy)-phenyl]-morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 1,1'-Oxybis(4-iodobenzene) | HCID 34360 | — |
| 반응물 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 반응물 | sodium 2-methylpropan-2-olate | HCID 178418730 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[4-(4-Iodo-phenoxy)-phenyl]-morpholine | HCID 23627788 | 99% |
반응 단계
The title compound (0.36 g, 99%) was prepared from 4-iodopheyl ether (0.42 g, 1 mmol) and morpholine (0.087 g, 1 mmol) in the presence of Pd2(dba)3 (0.027 g, 0.03 mmol), PtBu3 (0.058 g. 0.28 mmol) and NaO-t-Bu (0.095 g, 1 mmol) in toluene by using the procedure described in step 1 of Example 17: MS (ESI) m/z 382 (M+H); 1H NMR (400 MHz, CDCl3) δ 3.12 (t, J=4.8, 4H), 3.87 (t, J=4.8 Hz, 4H), 6.69-6.72 (m, 2H), 6.89-6.92 (m, 4H), 7.55-7.57 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07750012B2 |
| 출처 데이터셋 | uspto-grants-2010_07 |
| ORD ID | ord-d338b8ca4dc44c5c8f99637785b18744 |
| 출처 메모 | uspto-grants-2010_07 |