反应详情

The title compound (0.36 g, 99%) was prepared from 4-iodopheyl ether (0.42 g, 1 mmol) and morpholine (0.087 g, 1 mmol) in the presence of Pd2(dba)3 (0.027 g, 0.03 mmol), PtBu3 (0.058 g. 0.28 mmol) and NaO-t-Bu (0.095 g, 1 mmol) in toluene by using the procedure described in step 1 of Example 17: MS (ESI) m/z 382 (M+H); 1H NMR (400 MHz, CDCl3) δ 3.12 (t, J=4.8, 4H), 3.87 (t, J=4.8 Hz, 4H), 6.69-6.72 (m, 2H), 6.89-6.92 (m, 4H), 7.55-7.57 (m, 2H).