Morpholine → 4-(4-Nitropyridin-2-yl)morpholine

HRID 2353548

반응식

HRID 2353548 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 707344-Nitropyridine

생성물 1

HCID 574185464-(4-Nitropyridin-2-yl)morpholine수율 56.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

후처리

  1. customThe solvent was evaporated
  2. customthe residue purified by column chromatography (2/1 Hex/EtOAc)

출처 및 근거

ORD 기록
ord-2980c9148a43422cb224823d9fcf9fe8
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07749999B2

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