Isopropyl isocyanate → 3-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]-1-propan-2-yl-urea

HRID 2353637노트

반응식

HRID 2353637 반응식
[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:9]=[C:8]([C:18]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=2)[N:7]=1)(=[O:4])=[O:3].[CH:25]([N:28]=[C:29]=[O:30])([CH3:27])[CH3:26]>O1CCOCC1>[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:9]=[C:8]([C:18]2[CH:24]=[CH:23][C:21]([NH:22][C:29](=[O:30])[NH:28][CH:25]([CH3:27])[CH3:26])=[CH:20][CH:19]=2)[N:7]=1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 61277Isopropyl isocyanateHCID 593800394-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

생성물 1

HCID 248046593-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]-1-propan-2-yl-urea수율 43.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]aniline (70 mg, 0.2 mmol) and isoproylisocyanate (0.1 mL, 1 mmol) were heated in dioxane (2 mL) at 70° C. for 4 hours. The reaction mixture was evaporated and the residue triturated with ethyl acetate. The suspension was filtered and the white solid washed with ethyl acetate and diethyl ether then dried under vacuum at 60° C. overnight to yield the title compound (38 mg).

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue triturated with ethyl acetate
  3. filtrationThe suspension was filtered
  4. washthe white solid washed with ethyl acetate and diethyl ether
  5. customthen dried under vacuum at 60° C. overnight

출처 및 근거

ORD 기록
ord-3c09b0b3478244208be315ca3b1b4eb4
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750003B2

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