N-Iodosuccinimide → HCID 67035019, 화합물

HRID 2354093노트

반응식

HRID 2354093 반응식
[CH2:1]=[C:2]1[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH2:3]1.[I:9]N1C(=O)CCC1=O>C(Cl)Cl>[I:9][CH2:1][C:2]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][CH2:3]2

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 138082884-methylenecyclohexanol

생성물 1

HCID 67035019HCID 67035019, 화합물수율 37.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-methylenecyclohexanol (1.88 g) in CH2Cl2 (37.6 mL) was added N-iodosuccinimide (4.5 g) under nitrogen atmosphere, which was stirred at ambient temperature for 3 hours. The resultant was washed with Na2S2O3 aq., H2O, and brine. The organic phase was dried over Na2SO4, filtered, and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 1-(iodomethyl)-7-oxabicyclo[2.2.1]heptane (1.5 g) as colorless oil.

후처리

  1. washThe resultant was washed with Na2S2O3 aq., H2O, and brine
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-c3bf2cdcacfb4b2db56473b55a35f981
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750155B2

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