Triethyl phosphite → Diethyl [(2-bromophenyl)methyl]phosphonate

HRID 2354110노트

반응식

HRID 2354110 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>C1(C)C(C)=CC=CC=1>[CH2:12]([O:11][P:10]([CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[Br:1])(=[O:17])[O:14][CH2:15][CH3:16])[CH3:13]

참가 물질

4

반응물 2

HCID 31215Triethyl phosphiteHCID 769652-Bromobenzyl bromide

생성물 1

HCID 12703598Diethyl [(2-bromophenyl)methyl]phosphonate

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
80 °C

실험 절차

2-Bromobenzyl bromide (1048 g, 4.2 mol) was melted in a water bath of 60° C. and dissolved in xyleen (734 ml). The solution was heated to 80° C. Next triethyl phosphite (766 ml, 4.46 mol) was added in three equal portions to the reaction mixture in 60 minutes. The mixture was stirred overnight at 110° C. The reaction mixture was co-evaporated twice with 400 ml of xylene. The xylene was removed in vacuo at 60° C. The product was dried in a vacuum oven at 60° C. and was used without further purification.

후처리

  1. dissolutiondissolved in xyleen (734 ml)
  2. customThe xylene was removed in vacuo at 60° C
  3. customThe product was dried in a vacuum oven at 60° C.
  4. customwas used without further purification

출처 및 근거

ORD 기록
ord-24c9227083cf48d88a7b38cbe4dcb2bc
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750167B2

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