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Potassium Carbonate → N-cyclopropyl-3-[6-(2-hydroxy-2-methyl-3-pyrrolidin-1-ylpropoxy)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide

HRID 2354202
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HRID 2354202 반응식
CC1C=CC(S(O[CH2:12][C:13]([OH:41])([CH3:40])[CH2:14][O:15][C:16]2[CH:17]=[C:18]3[C:23](=[CH:24][CH:25]=2)[N:22]=[CH:21][N:20]([C:26]2[CH:31]=[C:30]([C:32]([NH:34][CH:35]4[CH2:37][CH2:36]4)=[O:33])[CH:29]=[CH:28][C:27]=2[CH3:38])[C:19]3=[O:39])(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+].[NH:48]1[CH2:52][CH2:51][CH2:50][CH2:49]1>CN(C=O)C>[CH:35]1([NH:34][C:32](=[O:33])[C:30]2[CH:29]=[CH:28][C:27]([CH3:38])=[C:26]([N:20]3[C:19](=[O:39])[C:18]4[C:23](=[CH:24][CH:25]=[C:16]([O:15][CH2:14][C:13]([OH:41])([CH3:40])[CH2:12][N:48]5[CH2:52][CH2:51][CH2:50][CH2:49]5)[CH:17]=4)[N:22]=[CH:21]3)[CH:31]=2)[CH2:37][CH2:36]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 86610962HCID 86610962, 화합물

생성물 1

HCID 11282934N-cyclopropyl-3-[6-(2-hydroxy-2-methyl-3-pyrrolidin-1-ylpropoxy)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide수율 30.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of the crude 3-[(3-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-oxo-3,4-dihydroquinazolin-6-yl)oxy]-2-hydroxy-2-methylpropyl 4-methylbenzenesulfonate (0.2 g) in anhydrous DMF (10 ml) was added potassium carbonate (0.1 g) followed by pyrrolidine (0.15 g) and the mixture stirred at room temperature for 18 hours. The mixture was concentrated and purification by preparative HPLC provided the title compound as a gum (50 mg); NMR Spectrum: (CDCl3) 0.60 (m, 2H), 0.90 (m, 2H), 1.20 (m, 1H), 1.40 (s, 3H), 1.80 (m, 4H), 2.20 (s, 3H), 2.75 (m, 6H), 4.20 (m, 2H), 6.40 (s, 1H), 7.50 (m, 2H), 7.70 (m, 3F[), 7.80 (d, 1H), 7.90 (s, 1H); Mass Spectrum: M+H+ 477.

후처리

  1. concentrationThe mixture was concentrated
  2. custompurification by preparative HPLC

출처 및 근거

ORD 기록
ord-2b96e871e402458ba14a29b9a18ef710
출처 데이터셋
uspto-grants-2010_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07750154B2

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