Triethylamine → N-(4-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-2-chloro-ethanesulfonamide

HRID 2354260

반응식

HRID 2354260 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:26]=[CH:25][C:16]([O:17][CH2:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:15]([CH3:27])[CH:14]=2)([CH2:11][CH3:12])[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:28].[Cl:29][CH2:30][CH2:31][S:32](Cl)(=[O:34])=[O:33].C(N(CC)CC)C>>[CH3:21][C:20]([CH3:22])([CH3:23])[C:19](=[O:24])[CH2:18][O:17][C:16]1[CH:25]=[CH:26][C:13]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:32]([CH2:31][CH2:30][Cl:29])(=[O:34])=[O:33])=[C:3]([CH3:28])[CH:4]=2)([CH2:11][CH3:12])[CH2:9][CH3:10])=[CH:14][C:15]=1[CH3:27]

참가 물질

4

반응물 3

HCID 8471TriethylamineHCID 15385Ethanesulfonylchloride, 2-chloro-HCID 684529431-{4-[1-(4-Amino-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one

생성물 1

HCID 58775973N-(4-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-2-chloro-ethanesulfonamide수율 98.4%

실험 절차

Using a procedure analogous to Example 17, 1-{4-[1-(4-amino-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (382 mg, 1 mmol), 2-chloro-ethanesulfonyl chloride (0.1 mL, 1 mmol) and triethylamine (0.14 mL, 1 mmol) give the title compound as a oil (500 mg, quant.)

출처 및 근거

ORD 기록
ord-759a474cbc84409e98570f0bd272aa02
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750184B2

연결된 노트

불러오는 중…