Sodium Hydroxide → [4-(2-Amino-4-methyl-thiazol-5-yl)-phenyl]-cyclopropyl-methanone
반응식
[OH-].[Na+].[CH:3]1([C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[S:18][C:17]([NH:19]C(=O)C)=[N:16][C:15]=3[CH3:23])=[CH:10][CH:9]=2)=[O:7])[CH2:5][CH2:4]1>C(O)C>[NH2:19][C:17]1[S:18][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([CH:3]3[CH2:5][CH2:4]3)=[O:7])=[CH:9][CH:10]=2)=[C:15]([CH3:23])[N:16]=1참가 물질
4
반응 조건
- 온도
- 85 °C
실험 절차
Ethanol (34 ml) and 6M NaOH (18.6 ml, 113.2 mmol) were added to N-[5-(4-Cyclopropanecarbonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (3.4 g, 11.32 mmol). The reaction mixture was heated to 85° C. for 5.5 hours, after which further NaOH (3.72 ml, 22.64 mmol) was added and heating continues for 1.5 hours. The resulting precipitate was isolated by vacuum filtration. (M+H) 301.26.