Hydrochloric Acid → 3-(4-Fluorophenoxy)pyrrolidine

HRID 2355167노트

반응식

HRID 2355167 반응식
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1.C(O)C>[F:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)=[CH:16][CH:17]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 50999115Tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate

생성물 1

HCID 218981593-(4-Fluorophenoxy)pyrrolidine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 312751,4-Dioxane용매

실험 절차

4N hydrogen chloride in dioxane (200 ml) is added to a solution of 3-(4-fluoro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 5 (39.43 g, 140 mmol) in ethanol (200 ml) and the mixture stirred at room temperature for 18 hours. The solvent is evaporated under vacuum and the residue basified using 4N sodium hydroxide solution (200 ml). The resulting product is extracted using DCM (3×100 ml). The organic extracts are dried (using MgSO4), filtered and evaporated to give the title compound as a light brown oil.

후처리

  1. customThe solvent is evaporated under vacuum
  2. extractionThe resulting product is extracted
  3. dry with materialThe organic extracts are dried (using MgSO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-f74877a49c85405a9d30ffc0c07e2c8b
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754758B2

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