Hydrochloric Acid → [4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1)

HRID 2355294노트

반응식

HRID 2355294 반응식
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=1)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2794813tert-Butyl [4-(hydroxymethyl)benzyl]carbamate

생성물 1

HCID 46738133[4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

반응 조건

온도
50 °C

실험 절차

Add 4N hydrogen chloride in 1,4-dioxane (25 mL) to a solution of (4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (3.0 g, 12.6 mmol) in 1,4-dioxane (25 mL). Heat the reaction mixture at 50° C. for 1 hr. Filter the solid and wash it with ethyl acetate to give the title compound (2.1 g, 12.1 mmol).

후처리

  1. filtrationFilter the solid
  2. washwash it with ethyl acetate

출처 및 근거

ORD 기록
ord-878e544899e94d0f8188516809875dcf
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754742B2

반응 노트

불러오는 중…