Acrylic Acid → 4-Methoxy cinnamic acid
반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[CH2:12].C(N(CC)CC)C>Cl[Pd]Cl.O>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([CH:12]=[CH:11][C:10]([OH:14])=[O:13])=[CH:3][CH:4]=1참가 물질
6
반응 조건
- 온도
- 130 °C
실험 절차
p-bromo anisole (8.4 g), acrylic acid (3.9 g), water (13.5 g), PdCl2 (0.3 mg) and triethyamine (14.3 g, 89.3% pure by titration, the balance being water, recovered by phase separation from a previous run) were charged into an autoclave and heated for 2 hours at 130° C. The work up detailed in Example 1 gave 6.5 g (81%) of >98% pure p-methoxy cinnamic acid.
후처리
- customrecovered by phase separation from a previous run)
- additionwere charged into an autoclave
출처 및 근거
- ORD 기록
- ord-623e76f5d131438c908eae7b5ce8e7ac
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05728865
반응 노트
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