Phosphorus oxychloride → Methyl 4-(6-chloropyridin-3-yl)benzoate

HRID 2356087노트

반응식

HRID 2356087 반응식
O[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178497536HCID 178497536, 화합물

생성물 1

HCID 22730372Methyl 4-(6-chloropyridin-3-yl)benzoate

실험 절차

A solution of Example 252E (1.2 g, 5 mmol) in POCl3 (30 mL) was heated to reflux for 30 minutes. The excess POCl3 was removed under vacuum and the remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes to provide the desired product. MS (ESI) m/e 248 (M+H)+.

후처리

  1. temperatureto reflux for 30 minutes
  2. customThe excess POCl3 was removed under vacuum
  3. customthe remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-9d8c404d0cd641c996079a93cfa82114
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754886B2

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