Sodium Carbonate → HCID 13537214, 화합물

HRID 235653

반응식

HRID 235653 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][CH3:9])[CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+].Cl.[Cl:17][C:18]1[CH:27]=[C:26]2[C:21]([C:22]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=3)=[CH:23][N:24]=[N:25]2)=[CH:20][CH:19]=1>C(Cl)(Cl)Cl.O>[Cl:17][C:18]1[CH:27]=[C:26]2[C:21]([C:22]([NH:28][C:29]3[CH:30]=[CH:31][C:32]([S:35]([NH:1][CH:2]4[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][CH3:9])[CH2:3]4)(=[O:36])=[O:37])=[CH:33][CH:34]=3)=[CH:23][N:24]=[N:25]2)=[CH:20][CH:19]=1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 980943-amino-N-ethylpiperidineHCID 21273956HCID 21273956, 화합물

생성물 1

HCID 13537214HCID 13537214, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

반응 조건

온도
3 °C

실험 절차

3-Amino-1-ethylpiperidine (0.4 ml) in chloroform (15 ml) was treated with anhydrous sodium carbonate (2.94 g) in water (15 ml) and cooled to 3° C. The mixture was vigorously stirred and treated with 4-(7-chloro-4-cinnolinylamino)benzenesulphonylchloride hydrochloride (1.0 g). The dark orange mixture was stirred at 3° C. for 15 minutes, then at room temperature for 45 minutes. During this period the colour lightened considerably. The chloroform layer was separated and dried over magnesium sulphate. The residue on evaporation solidified when triturated with methanol, to give the title compound (0.5 g), m.p. 213°-15° C. (with decomposition).

후처리

  1. stirringThe dark orange mixture was stirred at 3° C. for 15 minutes
  2. waitDuring this period the colour lightened considerably
  3. customThe chloroform layer was separated
  4. dry with materialdried over magnesium sulphate
  5. customThe residue on evaporation
  6. customtriturated with methanol

출처 및 근거

ORD 기록
ord-f64cd5b988b14d4f8e6425d0bb08320b
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640920

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