Thionyl Chloride → Ethyl 6-(chloromethyl)pyridine-2-carboxylate--hydrogen chloride (1/1)

HRID 2356608

반응식

HRID 2356608 반응식
O[CH2:2][C:3]1[N:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[Cl:16][CH2:2][C:3]1[N:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 109211412-Pyridinecarboxylic acid, 6-(hydroxymethyl)-, ethyl ester

생성물 1

HCID 68457584Ethyl 6-(chloromethyl)pyridine-2-carboxylate--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

As for Reaction 1, using 45.14 g of ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate and 33 g thionyl chloride in 500 ml dichloromethane. Yield 59.9 g

후처리

  1. customAs for Reaction 1

출처 및 근거

ORD 기록
ord-183871bb9e68456ba638c22d39f17ad6
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759369B2

연결된 노트

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