Acryloyl chloride → n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-acrylamide

HRID 2356938노트

반응식

HRID 2356938 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([N:13]2[C:17](=[O:18])[C:16]([CH3:20])([CH3:19])[N:15]([CH2:21][C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)[C:14]2=[O:28])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[C:29](Cl)(=[O:32])[CH:30]=[CH2:31]>ClCCCl>[CH3:19][C:16]1([CH3:20])[C:17](=[O:18])[N:13]([C:4]2[CH:5]=[CH:6][C:7]([O:8][C:9]([F:10])([F:11])[F:12])=[C:2]([NH:1][C:29](=[O:32])[CH:30]=[CH2:31])[CH:3]=2)[C:14](=[O:28])[N:15]1[CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 13140Acryloyl chlorideHCID 231103083-(3-Amino-4-trifluoromethoxyphenyl)5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione

생성물 1

HCID 23110311n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-acrylamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

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온도
-20 °C

실험 절차

1000 mg (2.54 mmol) 3-(3-amino-4-trifluormethoxy-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione were dissolved in 25 ml 1,2-dichloroethane. The mixture was cooled to −20° C. and treated with a solution of 272 mg (3.00 mmol) acrylic acid chloride in 5 ml 1,2-dichloroethane. The mixture was allowed to reach RT, and then evapoarted to dryness. The raw material was used without further purification.

후처리

  1. customto reach RT
  2. customThe raw material was used without further purification

출처 및 근거

ORD 기록
ord-d25fd5b1f425402fac1fb9b7d0cc1b45
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759379B2

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